Radionuclides
We provide cyclotron and reactor produced radionuclides for research & medical use.
The Radionuclide Section provides a wide number of cyclotron and reactor produced radionuclides for research as well as for medical and technical applications. The Hevesy Laboratory operates multiple cyclotrons: two PETtrace 800, that provide proton beams of up to 16.5 MeV and deuteron beams of up to 8.4 MeV, one GENtrace and one experimental cyclotron, both providing proton beams of up to 7.8 MeV. In addition to that, reactor produced radionuclides are available by neutron irradiation of targets that take place at different reactors in Europe and the US. After the irradiation cycle at the reactor, the irradiated target material is returned to the Hevesy Laboratory where it is further processed for internal use or as final products for distribution to customers in Denmark and abroad.
Products in this category:
Specification sheet [64Cu]CuCl2
|
Parameter |
Specification |
|
Production route (cyclotron) |
Ni-64(p,n)Cu-64 |
|
Decay |
Decays to stable Ni-64 and stable Zn-64: 17.6% β+, 43.9% EC, 38.5% β- |
|
Half-life |
12.7 h |
|
Processing |
One step cation exchange chromatography |
|
Primary Container |
10 mL borosilicate glass vial with silicone rubber and aluminium cap |
|
Product Grade |
n.c.a. |
|
Physical Form |
Solid |
|
Chemical form |
CuCl2 in dry form |
|
Radioactive Concentration (gamma spectrometry) |
n.a. |
|
Appearance |
Invisible deposit at bottom of glass vial |
|
Radionuclide Identification (gamma spectrometry) |
1346 keV gamma line and 511 keV annihilation gamma line present |
|
Radionuclidic purity (gamma spectrometry) |
>99.9% at calibration time (Co-56, Co-57, Co-58 each below 0.01%) |
|
Chemical purity (ICP-OES) |
Cu, Ni, Zn, Co and Fe each <1 µg per GBq Cu-64 |
|
Molar activity (ICP-OES) |
>500 GBq/µmol at calibration time (>5% of theoretical maximum) |
|
Apparent Molar Activity |
>100 GBq/µmol (DOTA labelling) at calibration time |
|
Bacterial endotoxin |
<175/V IU/ml (V being the maximum volume to be used for the preparation of a single patient dose) |
|
pH (pH strips) |
n.a. |
|
Additional information |
|
|
Activity available |
1 – 12 GBq |
|
Activity limit for UN2910 (excepted package) shipment |
1 GBq in dry state or 0.1 GBq in liquid form |
|
Other information |
Product is normally shipped in dry state, in “empty vials” but ready for reconstitution with what buffer the user prefers, and then ready for labelling of e.g. DOTA-compounds. Upon request, product can be shipped in 0.05 M HCl (1-2 ml) or Ammonium Acetate buffer (1 M, 1-2 ml). Bioburden and endotoxin burden can be analysed post release, upon request |
Specification sheet [67Cu]CuCl2
|
Parameter |
Specification |
|
Production route (cyclotron) |
Zn-70(p,α)Cu-67 |
|
Decay |
β− radiation (mean β− energy: 141 keV; Eβ−max: 562 keV) and γ-rays (93 and 185 keV) decays to stable Zn-67 |
|
Half-life |
2.58 d |
|
Processing |
Two step extraction chromatography |
|
Primary Container |
2.5 mL borosilicate glass vial with silicone rubber and aluminium cap |
|
Product Grade |
n.c.a. |
|
Physical Form |
Liquid or Solid deposit |
|
Chemical form |
Dry form CuCl2 or aq. solution |
|
Radioactive Concentration (gamma spectrometry) |
n.a. |
|
Appearance |
non-visible deposit |
|
Radionuclide Identification (gamma spectrometry) |
The gamma lines 91, 93, 185, 300 & 393 keV present and internal ratios corresponding to NuDat2 data |
|
Radionuclidic purity (gamma spectrometry) |
>99,8 % at EOB |
|
Chemical purity (ICP-OES) |
Cu, Zn, Sn and Fe each <1 µg and Ca and Al present in <5 µg per batch Cu-67 |
|
Molar activity (ICP-OES) |
> 10 MBq/nmole |
|
Apparent Molar Activity |
> 9 MBq/nmole by DOTA-titration |
|
Bacterial endotoxin |
Not determined |
|
pH (pH strips) |
Depends on chemical form |
|
Additional information |
|
|
Activity available |
120 MBq |
|
Activity limit for UN2910 (excepted package) shipment |
0.7 GBq in dry state or 70 MBq in liquid form |
|
Other information |
Product is normally shipped in dry state, in “empty vials” but ready for reconstitution with what buffer the user prefers, and then ready for labelling of e.g. DOTA-compounds. Bioburden and endotoxin burden can be analysed post release, upon request |
Specification sheet [135La]LaCl3
|
Parameter |
Specification |
|
Production route (cyclotron) |
Ba-135(p,n)La-135 |
|
Decay |
Decays to stable Ba-135: 99.993% EC, 0.007% β+ |
|
Half-life |
18.91 h |
|
Processing |
Precipitation and one step extraction chromatography |
|
Primary Container |
10 mL borosilicate glass vial with silicone rubber and aluminium cap |
|
Product Grade |
n.c.a. |
|
Physical Form |
Liquid or Dry |
|
Chemical form |
La3+ion in 0.1 M HCl solution (1-2 ml) or other HCL concentration or dry |
|
Radioactive Concentration (gamma spectrometry) |
n.a. |
|
Appearance |
Clear colourless solution |
|
Radionuclide Identification (gamma spectrometry) |
481 keV and 875 keV gamma lines present |
|
Radionuclidic purity (gamma spectrometry) |
>99 % |
|
Chemical purity (ICP-OES) |
Metal impurities determined by ICP-OES for each batch. Typical 40 nmol Al, 0,3 nmol Ba, 1 nmol Fe, 1 nmol Zn and 1 nmol La |
|
Molar activity (ICP-OES) |
Typical 1000 GBq/µmol La at End of Separation (>15% of theoretical maximum) |
|
Apparent Molar Activity |
50 – 100 GBq/µmol DOTA labeling decay corrected to EOB |
|
Bacterial endotoxin |
Bioburden and endotoxin burden can be analysed post release, upon request |
|
pH (pH strips) |
Depends on chemical form |
|
Additional information |
|
|
Activity available |
Up to 1 GBq upon request |
|
Activity limit for UN2910 (excepted package) shipment |
20 MBq in dry state or 2 MBq in liquid form |
|
Other information |
Product is shipped in liquid or dry state as per request. Bioburden and endotoxin burden can be analysed post release, upon request |
Specification sheet [52Mn]MnCl2
|
Parameter |
Specification |
|
Production route (cyclotron) |
Cr-52(p,n)Mn-52 |
|
Decay |
Decays to stable Cr-52: 29.4% β+, 70.6% EC |
|
Half-life |
5.59 d |
|
Processing |
Extraction chromatography |
|
Primary Container |
10 mL borosilicate glass vial with silicone rubber and aluminium cap |
|
Product Grade |
n.c.a. |
|
Physical Form |
Liquid or Solid form |
|
Chemical form |
Mn2+ion in 0.1 M HCl solution (1-2 ml) |
|
Radioactive Concentration (gamma spectrometry) |
n.a. |
|
Appearance |
Clear colourless solution or invisible dried deposit |
|
Radionuclide Identification (gamma spectrometry) |
744 keV, 936 keV and 1434 keV gamma lines and 511 keV annihilation gammas present |
|
Radionuclidic purity (gamma spectrometry) |
>99 % |
|
Chemical purity (ICP-OES) |
Not determined |
|
Molar activity (ICP-OES) |
> 200 GBq/µmol Mn at End of Separation (>30% of theoretical maximum) |
|
Apparent Molar Activity |
Not applicable |
|
Bacterial endotoxin |
Bioburden and endotoxin burden can be analysed post release, upon request |
|
pH (pH strips) |
Depends on chemical form |
|
Additional information |
|
|
Activity available |
Up to 0.4 GBq |
|
Activity limit for UN2910 (excepted package) shipment |
0.3 GBq in dry state or 30 MBq in liquid form |
|
Other information |
Product is shipped in liquid or dry state as per request. Bioburden and endotoxin burden can be analysed post release, upon request |
Specification sheet [165Er]ErCl3
|
Parameter |
Specification |
|
Production route (cyclotron) |
Ho-165(p,n)Er-165 |
|
Decay |
Decays to stable Ho-165: 100% EC |
|
Half-life |
10.36 h |
|
Processing |
Multi-step extraction chromatography |
|
Primary Container |
10 mL borosilicate glass vial with silicone rubber and aluminium cap |
|
Product Grade |
n.c.a. |
|
Physical Form |
Liquid |
|
Chemical form |
Er3+ion in 0.1 M HCl solution (1-2 ml) |
|
Radioactive Concentration (gamma spectrometry) |
Up to 1 GBq/ml |
|
Appearance |
Clear colourless solution |
|
Radionuclide Identification (gamma spectrometry) |
X-Rays: 6,7 keV, 46,7 keV, 47,5 keV, 53,7 keV, 53,9 keV and 44,3 keV |
|
Radionuclidic purity (gamma spectrometry) |
t.b.d |
|
Chemical purity (ICP-OES) |
t.b.d |
|
Molar activity (ICP-OES) |
t.b.d |
|
Apparent Molar Activity |
t.b.d |
|
Bacterial endotoxin |
Bioburden and endotoxin burden can be analysed post release, upon request |
|
pH (pH strips) |
t.b.d |
|
Additional information |
|
|
Activity available |
Up to 1 GBq upon request |
|
Activity limit for UN2910 (excepted package) shipment |
20 MBq in dry state or 2 MBq in liquid form |
|
Other information |
Product is shipped in liquid or dry state as per request. Bioburden and endotoxin burden can be analysed post release, upon request |
Specification sheet [82Br]KBr
|
Parameter |
Specification |
|
Production route (reactor) |
natBr(n, γ)82Br |
|
Half-life |
1.47 day |
|
Primary Container |
25 mL borosilicate glass vial with silicone rubber and aluminium cap |
|
Physical Form |
Liquid |
|
Chemical form |
[82Br]KBr in water |
|
Radioactive Concentration (gamma spectrometry) |
10 MBq/ml |
|
Appearance |
Clear colourless solution |
|
Additional information |
|
|
Maximum activity in vial |
220 MBq |
|
Packing Container |
Type A tungsten container and a flight case from COMECER |
Sources
Hevesy Laboratory produces four different types of sealed demonstration sources: 137Cs, 90Sr/90Y, 241Am and 60Co. These sources are approved for educational use in schools in Denmark, Norway and Sweden.
|
Type |
Isotope |
Activity |
Half-life |
|
Gamma |
Cs-137 |
370 kBq |
30.1 y |
|
Gamma |
Co-60 |
260 kBq |
5.3 y |
|
Beta |
Sr-90/Y-90 |
37 kBq |
28.0 y |
|
Alpha |
Am-241 |
37 kBq |
432.7 y |
Hevesy Laboratory produces these sources on a demand basis.